MOTS-c — 10mg

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide (MDP) encoded within the mitochondrial genome — specifically within the 12S ribosomal RNA gene. Its discovery marked a significant advance in mitochondrial biology, establishing that the mitochondrial genome encodes bioactive peptides capable of systemic signalling. MOTS-c is now one of the most actively researched compounds in metabolic biology, cellular stress response, and longevity science.

Mechanism of Interest
MOTS-c primarily acts by translocating to the nucleus in response to metabolic stress, where it regulates gene expression related to glucose metabolism, fatty acid oxidation, and cellular homeostasis. It activates AMPK (AMP-activated protein kinase) — a master regulator of cellular energy balance — and has been shown in research models to influence insulin sensitivity, mitochondrial function, and age-related metabolic decline. Its unique origin within the mitochondrial genome makes it a distinct and highly novel research tool.

Research Focus Areas
• Mitochondria-derived peptide (MDP) signalling research
• AMPK activation and cellular energy homeostasis
• Insulin sensitivity and glucose metabolism models
• Fatty acid oxidation and lipid metabolism studies
• Mitochondrial function and biogenesis research
• Cellular stress response and adaptive signalling
• Metabolic ageing and longevity biology
• Exercise-mimetic and physical performance models

Specifications
• Total content: 10mg
• Form: Lyophilised powder
• Purity: ≥99% — HPLC verified
• Storage: 2–8°C, away from light and moisture

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Important Notice

This product is supplied strictly for laboratory research use only. It is not intended for human or veterinary use.

By purchasing, the buyer confirms they are a qualified professional or acting on behalf of a licensed research facility and accept full responsibility for safe handling, storage, and use in accordance with all applicable guidelines. No claims are made regarding the safety or effectiveness of this compound outside of a controlled research environment.